Avian Embryos (Pt 1)

 

CAMsmaller

The laboratory relies on two animal models for simulating metastasis: the mouse model and the avian embryo model.  The mouse model is obviously the gold standard for evaluating anti-cancer drugs and determining if there is a loss of metastatic burden in the lung/iver/brain or not.

However, the avian embryo its in ex ovo format, is an incredibly powerful animal model for understanding the metastatic cascade and the molecular mechanisms driving it.  This is a top down view of the avian embryo.  That highly vascularized vessel bed covering the embryo is the chorioallantoic membrane (CAM) and its essentially the “lung” of the embryo.  Once attached to the inside wall of the egg shell, when cracked open, we can inject cancer cells intravenously into the CAM and watch the critical steps of extravasation and secondary colony formation.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s