Ultrasound imaging of PDX tumor vasculature 

While looking through a microscope might offer some insight regarding tumor size and viability, in order to determine if an anti-angiogenesis drug is having any real impact on tumor vasculature, you’ll need to image tumor perfusion within the tumor.  To do this, we use contrast-based ultrasound imaging to visualize the tumor vasculature and get blood flow kinetics.  Chantalle and I came up with this idea after talking to Matt Lowerison and Dr. James Lacefield.  Now, its the only way we evaluate PDX viability!