Above are three prostate microparticles from PCa patient plasma.  I love AFM because it provides exquisite topographical detail and also gives you nanometer-angstrom scale volumetrics.  These PCMPs are tiny – average diameter (max XY) appears to be 200nm.  The max height about 50-80nm.  My imaging modality of choice is AFM.  If I could do magnetic AFM I would!  Sabine will have a paper out pretty soon on SNOM imaging of purified PMCPs, but I won’t let the idea out of the bag, or she’ll kill me!