Prostate Cancer + Bone Xenografts

PCa bone onplants

I think everyone realizes that there’s something “particular” about prostate cancer bone metastases and the mineralized hydroxyapatite that surrounds these metastases.  I had the recent pleasure of conversing with Dr. Leland Chung, the person who discovered that RANKL antagonization might be beneficial for these patients.  We’ve been working on a prostate cancer bone metastasis model where we mix PC-3M-LN4 cells with modified hydroxyapatite and they form very nice “xenografts”.  Next step: adipocytes!

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