Using shRNA libraries provided by Dr. Jason Moffat, we have identified several tumor suppressors for prostate cancer using 3D based functional genomics screens of BPH cells.  We now apply these screens to identify regulators of androgen signalling in prostate cancer cells as well as dormancy breaking genes.

Team: Sean Leith, Milica Krstic, Slavic Fedyshyn, David Dales, Joseph Andrews, Dr. Ann Chambers, Susan Kuruvilla, Dr. Joseph Chin

Grants:

CRLP Internal Grant $25,000

PCC Movember Pilot Grant $150,000

Prostate Care Centre Studentship: $42,000