The research approach here is a “processes” attitude towards understanding and antagonizing cancer metastasis. We use three main platforms/techniques to understand metastasis: 1) the chicken embryo as a model for visualizing each step of metastasis, 2) intravital imaging using resonance scanning confocal microscopy, and 3) functional genomics with CRISPR/shRNA lentivirus-based technology to modulate putative tumor suppressors/drivers of metastasis.
1. Invadopodia and their role in tumor cell intravasation
2. Functional Genomics screens for Tks5 expression
3. Induction of the Oligometastatic State in Metastatic Prostate Cancer
4. The anti-metastatic effects of excessive microparticle release during cancer cell extravasation
Team: Dr. Karla Williams, Lily Hou, Siddika Pardhan, Slavic Fedyshyn, Dr. Khurram Siddiqui
1. CUOG Grant – $50,000